※ 主要经历：

2010/10 - 至今， 厦门大学，化学化工学院化学生物学系，副教授，主要从事蛋白质和多肽的结构生物学研究。

2008/03 - 2010/10，美国马里兰大学，化学生物学系，生物分子实验室，访问学者，从事NMR技术在结构生物学中的应用研究。

2005/07 - 2008/2， 中国科学院上海药物研究所，助理研究员，从事基于NMR技术的结构生物学研究。

2000/09 - 2005/06，山西大学，生物技术研究所，博士。

1996/09 - 2000/06，山西大学，生命科学与技术学院，学士。

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※ 承担的本科生课程：

《化学生物学综合实验》，《生物化学实验》，《基础无机化学一》，《微生物学》，等等。

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※ 研究领域：

主要利用生物核磁共振技术开展蛋白质、多肽的结构和功能研究，已发表20多篇SCI论文。

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※ 基金项目：

参与项目：

1. 国家自然科学基金面上项目，No 31670741，朊病毒蛋白G127V多态性保护作用的结构基础，2017.1-2020.12，在研，主要学术骨干。
2. 国家重点研发计划，No 2016YFA0500600，病原菌核糖体调节因子的发现、鉴定及调控机制研究，2016.7-2021.6，在研，主要学术骨干。

主持项目：

3. 国家自然科学基金面上项目，No 31470034，Raf1激酶抑制蛋白RKIP与配体的复合物溶液结构和功能研究，2015/01-2016/12，在研。
4. 福建省自然科学基金面上项目，No 2011J01246，用NMR技术研究腺苷酸激酶AK1在催化过程中构象和动力学的变化，2011/04-2014/06，已结题。
5. 国家自然科学基金青年项目，No 30900233，RKIP磷酸化交叉调控MAPK信号通路与GPCR信号通路的分子机制和结构基础，2010/01-2012/12，已结题。

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※ 发表文章：

------通讯作者或第一作者SCI论文------

1. S. Tian, H. Chen, T. Sun, H. Wang, X. Zhang, Y. Liu, J. Xia, C. Guo*, D. Lin*, Expression, purification and characterization of Esx-1 secretion-associated protein EspL from Mycobacterium tuberculosis. Protein Expr Purif. 2016, 128:42-51. doi: 10.1016 / j. pep. 2016.08.001.
2. T. Sun, Z. Wu, M. Luo, D. Lin, C. Guo*, Pranlukast, a novel binding ligand of human Raf1 kinase inhibitory protein. Biotechnol Lett. 2016, 38(8):1375-80. doi: 10.1007/s10529-016-2117-0.
3. H. Chen, H. Wang, T. Sun, S. Tian, D. Lin, C. Guo*, Recombinant preparation and functional studies of EspI ATP binding domain from Mycobacterium tuberculosis. Protein Expr Purif. 2016, 123: 51-9. doi: 10.1016/j.pep.2016.03.009.
4. K. Lin, Z. Yu, Y. Yu, X. Liao, P. Huang, C. Guo*, D. Lin*, Distinct effects of Cu2+-binding on oligomerization of human and rabbit prion proteins, Acta Biochim Biophys Sin (Shanghai). 2015, 47(10): 842-850.
5. Z. Wu, C. Fu, L. Shi, L. Ruan, D. Lin, C. Guo*, Structural basis for RKIP binding with its substrate Raf1 kinase, Biotechnol Lett. 2014, 36(9):1869-1874.
6. C. Fu, Y. Peng, X. Liao, C. Guo*, D. Lin*, (1)H, (13)C, (15)N backbone and side-chain resonance assignments of the human adenylate kinase 1 in apo form, Biomol NMR Assign. 2013, 7(2): 155-158.
7. C. Guo#, C. Yi#, Y. Peng, Y. Wen, D. Lin*, Solution structure and backbone dynamics of human Raf-1 kinase inhibitor protein, Biochem Bioph Res Co. 2013, 438(1): 129-132.
8. C. Guo, R.Godoy-Ruiz, V.Tugarinov*, High resolution measurement of methyl 13C(m)-13C and 1H(m)-13C(m) residual dipolar couplings in large proteins. J. Am. Chem. Soc. 2010, 132: 13984-7.
9. C. Guo, Y. Lian, Q, Liu, J. Liu, Y. Zhang, D. Lin*, Soluble expression and characterization of a mouse epididymis- specific protein lipocalin6, Protein Expr. Puri.2010, 69: 64-7.
10. C. Guo, V. Tugarinov*, Selective 1H-13C NMR spectroscopy of methyl groups in residually protonated samples of large proteins, J. Biomol. NMR. 2010, 46:127-33.
11. C. Guo, C. Geng, V. Tugarinov*, Selective backbone labeling of proteins using 1,2-13C2 -pyruvate as carbon source, J. Biomol. NMR. 2009, 44: 167-73.
12. C. Guo, H. Diao, Y. Lian, H. Yu, H. Gao, Y. Zhang, D. Lin*, Recombinant expression and characterization of an epididymis-specific antimicrobial peptide BIN1b / SPAG11E, J. Biotechnol. 2009, 139: 33-7.
13. C. Guo, D. Zhang, V. Tugarinov*, A NMR experiment for simultaneous TROSY - based detection of amide and methyl groups in large proteins, J. Am. Chem. Soc. 2008, 130: 10872-3.
14. C. Guo, V. Tugarinov*, Identification of HN-Methyl NOEs in large proteins using simultaneous amide-methyl TROSY-based Detection, J. Biomol. NMR. 2008, 43: 21-30.
15. C. Guo, Z. Li, J. Yuan*, Preparation of an immunoadsorbent coupled with a recombinant antigen to remove anti-acetylcholine receptor antibodies in abnormal serum, J. Immunol. Method. 2005, 303:142-7.
16. C. Guo, Z. Li, Y. Shi, M. Xu, J.G.Wise, W.E. Trommer, J. Yuan* Intein-mediated fusion expression, high efficient refolding and one-step purification of gelonin toxin, Protein Expr. Puri. 2004, 37: 361-7.

    ------近五年来参与的SCI论文------

17. Y. Yu, Z. Yu, Z. Zheng, H. Wang, X. Wu, C. Guo, D. Lin*, Distinct effects of mutations on biophysical properties of human prion protein monomers and oligomers, Acta Biochim Biophys Sin (Shanghai). 2016 Sep 20, PMID: 27649893.
18. Z. Yu, P. Huang, Y. Yu, Z. Zheng, Z. Huang, C. Guo, D. Lin*, Unique Properties of the Rabbit Prion Protein Oligomer, PLoS One. 2016,11(8):e0160874. doi: 10.1371/journal.pone.0160874.
19. B. Huang, J. Fu, C. Guo, X. Wu, D. Lin, X. Liao*,1H, 15N, 13C resonance assignments for pyrazinoic acid binding domain of ribosomal protein S1 from Mycobacterium tuberculosis. Biomol NMR Assign. 2016 Jul 13. PMID: 27412769.
20. J. Yang, Y. Liu, J. Bi, Q. Cai, X. Liao, W. Li, C. Guo, Q. Zhang, T. Lin, Y. Zhao, H. Wang, J. Liu*, X. Zhang*, D. Lin*, Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide, Mol Microbiol. 2015, 95(5):791-803.
21. P. Huang, F. Lian, Y. Wen, C. Guo, D. Lin*, Prion protein oligomer and its neurotoxicity, Acta Biochim Biophys Sin (Shanghai), 2013, 45(6): 442-451.
22. Y. Gu, Q. Liu, P. Chen, C. Guo, Y. Liu, Y. Zhao, Y. Zhang, D. Lin*, Characterization of the oligomerization and ligand-binding properties of recombinant rat lipocalin 11, Biochim Biophys Acta. 2013, 1834(1): 1-7.
23. C. Wu, J. Hong, X. Liao, C. Guo, X. Wu, H. Hu, D. Lin*, (1)H, (13)C and (15)N backbone and side-chain resonance assignments of reduced CcmG from Escherichia coli, Biomol NMR Assign. 2013, 7(1): 105-108.
24. C. Yi, Y. Peng, C. Guo, D. Lin*， (1) H, (13)C, (15)N backbone and side-chain resonance assignments of the human Raf-1 kinase inhibitor protein, Biomol NMR Assign. 2011, 5(1) : 63-66.
25. X. Liao, R. Godoy-Ruiz, C. Guo, V. Tugarinov*, Simultaneous measurement of ¹H-15N and methyl ¹Hm-¹³Cm residual dipolar couplings in large proteins, J Biomol NMR, 2011, 51(1-2): 191-8.
26. Y. Peng, X. Zhang, J. Liu, Q. Liu, C. Guo, Y. Zhang, D. Lin*, Solution structure of the protein lipocalin 12 from rat epididymis, Proteins, 2011,79(7): 2316-2320.