课题组介绍

        本课题组依托于厦门大学高场核磁共振中心，拥有多台国际先进的高场核磁共振谱仪（850兆、600兆等），主要开展生物核磁共振谱学技术在化学、生物学、医学、药学、海洋科学和环境科学等方面的应用研究，包括结构生物学研究和代谢组学研究。 近年来，本课题组在国际学术刊物(Molecular Cancer，Molecular Cell, Nature Chemical Biology, Nature Communication, Theranostics, Journal of Cachexia, Sarcopenia and Muscle，Mol. Cell. Proteomics, Leukemia，FASEB, Cell Reports, Journal of Proteomics Research, Journal of Medicinal Chemistry, Journal of Cellular Physiology, Skeletal Muscle, Cancer Science, Free Radical Biology and Medicine, Journal of Biological Chemistry, Molecular Microbiology, International Journal of Molecular Science, Biomolecules, Applied Microbiology and Biotechnology , Frontiers in Pharmacology，Frontiers in Molecular Biosciences, Marine Drug, molecules, metabolites等）上发表SCI论文220 篇，5980 次（Google Schoolar 检索数据，2025/7/8）。我们热忱欢迎国内外研究团队与本课题组开展合作研究，也欢迎努力向上的青年学子报考本课题组研究生，也欢迎志同道合的青年博士来本课题组开展博士后和访问学者等研究工作。

       Relying on the High Field NMR Center of Xiamen University, which has several international advanced high field NMR spectrometers (850 MHz, 600 MHz, etc.), the group mainly carries out research on the application of biological NMR spectroscopy in chemistry, biology, medicine, pharmacy, marine science, and environmental science, including structural biology research and metabolomics research. In recent years, our group has been published in international academic journals (Molecular Cancer, Molecular Cell, Nature Chemical Biology, Nature Communication, Theranostics, Journal of Cachexia, Sarcopenia Proteomics, Leukemia, FASEB, Cell Reports, Journal of Proteomics Research, Journal of Medicinal Chemistry, Journal of Cellular Physiology, Skeletal Muscle, Cancer Science, Free Radical Biology and Medicine, Journal of Biological Chemistry, Molecular Microbiology, International Journal of Molecular Science, Biomedical Sciences, Mol. International Journal of Molecular Science, Biomolecules, Applied Microbiology and Biotechnology , Frontiers in Pharmacology, Frontiers in Molecular Biosciences, Marine Drug, molecules, metabolites, etc.),  220 SCI papers, 5980 times (Google Schoolar search data, 2025/7/8). We warmly welcome research teams from home and abroad to carry out collaborative research with our group, as well as hard-working young students to apply for postgraduate studies in our group, and like-minded young PhDs to carry out postdoctoral and visiting scholars and other research work in our group.

课题组介绍海报：

 生物核磁课题组介绍(Introduction to the Bio-NMR Group)

 NMR实验室谱仪性能介绍(NMR Laboratory Spectrometer Performance)

主要研究方向：

1. 结构生物学研究：

主要利用生物核磁共振技术和X-射线晶体衍射技术开展结构生物学研究，包括：

（1）测定蛋白质、多肽及其复合物的溶液结构或晶体结构；

（2）研究蛋白质、多肽与配体的相互作用；

（3）测定蛋白质的动力学；

（4）基于结构的药物筛选，等等。

结构生物学研究简介海报：

 生物核磁共振课题组研究简介墙报-结构生物学(Biological Nuclear Magnetic Resonance (BNMR) Group Research Briefing - Structural Biology)

Main Research Interests:

1. Structural biology research:

Structural biology research is mainly carried out using biological NMR techniques and X-ray crystal diffraction techniques, including:

(1) Determination of solution structure or crystal structure of proteins, polypeptides and their complexes;

(2) Studying the interaction of proteins, peptides and ligands;

(3) Determination of protein kinetics;

(4) Structure-based drug screening, and so on.

2. 代谢组学研究：

利用核磁共振技术开展代谢组学研究，包括：

（1）阐述重大疾病的代谢特征，发展早期诊断和术后检测方法；

（2）阐述疾病发生发展过程中代谢模式和谢物水平的变化和受扰动的代谢通路，揭示发病的分子机制，寻找逆转病理代谢状态的方法；

（3）评估药物的药效和毒性，阐明所干预的代谢通路和作用机制；

（4）运动人体的代谢特征与运动影响的特征性代谢物和作用的重要代谢通路。

所研究的生物样品：血清、血浆、尿液、唾液等生物体液，组织，细胞，微生物和粪便，等等。

代谢组学研究简介海报：

 生物核磁共振课题组研究简介墙报-代谢组学(Biological Nuclear Magnetic Resonance (BNMR) Group Research Briefing - Metabolomics)

2. Metabolomics studies:

Metabolomics research using NMR technology, including:

(1) Elaboration of metabolic characteristics of major diseases and development of early diagnosis and postoperative detection methods;

(2) Elaborate the changes in metabolic patterns and levels of metabolites and perturbed metabolic pathways during disease development, reveal the molecular mechanisms of pathogenesis, and find ways to reverse pathological metabolic states;

(3) To assess the efficacy and toxicity of drugs and to elucidate the metabolic pathways and mechanisms of action intervened;

(4) Metabolic characterization of the exercising human body with characteristic metabolites affected by exercise and important metabolic pathways of action.

Biological samples studied: serum, plasma, urine, saliva and other biological fluids, tissues, cells, microorganisms and feces, among others.

主要研究兴趣：

1. 结核分枝杆菌重要蛋白质的结构与功能研究，着重研究反式翻译过程关键蛋白的结构、动力学及其相互作用等，基于靶蛋白的结构设计和筛选先导化合物，克服抗结核病药物的耐药性。

2. 人源朊病毒蛋白及其致病突变体的结构、动力学研究， 着重研究G127V多态性保护作用的结构基础，理解朊病毒蛋白的致病机理，为朊病毒病的防治与药物研发提供理论依据

3. 肿瘤的代谢特征、生物标志物、紊乱的代谢通路和发病机制，曾开展过肝癌、大肠癌、肾癌和胶质瘤等代谢组学研究，目前正研究肠癌恶病质、胃癌恶病质、胶质瘤恶病质的代谢模式、特征性代谢物、关键代谢通路等， 尤其感兴趣肿瘤外泌体在肿瘤恶病质的发生发展中的作用。

4. 心血管病、糖尿病等代谢性疾病的代谢特征、生物标志物、关键代谢通路和发病机制等，尤其感兴趣红细胞在心血管、动脉粥样硬化和糖尿病等疾病发病过程中的作用。

Main Research Interests:

1. Structure and function of important proteins of Mycobacterium tuberculosis, focusing on the structure, dynamics and interactions of key proteins in the trans-translation process, and the structural design and screening of lead compounds based on target proteins to overcome resistance to anti-tuberculosis drugs.

2. Structural and kinetic studies of human prion protein and its pathogenic mutants, focusing on the structural basis of the protective effect of the G127V polymorphism, to understand the pathogenic mechanism of prion protein, and to provide a theoretical basis for the prevention and treatment of prion diseases and drug development.

3. Metabolic characteristics, biomarkers, disordered metabolic pathways and pathogenesis of tumors. We have carried out metabolomics studies on liver cancer, colorectal cancer, kidney cancer and glioma, and are currently studying the metabolic patterns, characteristic metabolites and key metabolic pathways of intestinal cancer, gastric cancer, and glioma malignant pathology, and we are particularly interested in the role of exosomes in malignant development of tumors.

4. Metabolic features, biomarkers, key metabolic pathways and pathogenesis of cardiovascular diseases, diabetes and other metabolic diseases, especially interested in the role of erythrocytes in the pathogenesis of cardiovascular diseases, atherosclerosis and diabetes.